Neuropsychiatric Syndromes in Dementia: Evolution, Risk Factors and Outcomes 

 
   Lead Investigator:    Jeannie Leoutsakos
   Institution      :    Johns Hopkins University School of Medicine
   E-Mail           :    jeannie-marie@jhu.edu
   Proposal ID      :    215


   Publications:


1  Leoutsakos JM
   Trajectories of NPS in Pre-clinical NACC (National Alzheimer Coordinating Center) Participants and Conversion to MCI and Dementia
   2016   Abstract  International College of Geriatric Psychopharmacology , 

   ACCEPTED



2  Leoutsakos JM
   Trajectories of NPS in Pre-clinical NACC (National Alzheimer Coordinating Center) Participants and Conversion to MCI and Dementia
   2017   Abstract  AAIC 2017 , 

   ACCEPTED



3  Leoutsakos JS, Forrester SN, Geda YE, Lyketsos C
   NPS in normal cognition and the risk of developing MCI and dementia in the presence of late onset NPS
   Abstract  Alzheimers Dement,11(7):309-310,2015,

   PUBLISHED





   Proposal Description:
   Abstract: We propose a secondary analysis of NACC data related to neuropsychiatric symptoms (NPS) in patients with dementia due to all causes. The overarching goal of the project is to study the longitudinal course of NPS using clinical data collected by the NACC. We aim to evaluate patterns of NPS occurrence and co-occurrence that lead to worse clinical outcomes (e.g., mortality or institutionalization), identify predictors of specific patterns of NPS, and examine the effects of modifiable factors (e.g., general medical health, care environment) on NPS course and co-occurrence. We plan to compare our results from the NACC dataset to data from the population-based Cache County Study on Memory in Aging (R01AG11380) its successor, the Cache County Dementia Progression Study (R01AG21136) and the AD Neuroimaging Initiative (ADNI).